diff --git a/drivers/tty/serial/fsl_lpuart.c b/drivers/tty/serial/fsl_lpuart.c
index e96354edff6e..011f17593613 100644
--- a/drivers/tty/serial/fsl_lpuart.c
+++ b/drivers/tty/serial/fsl_lpuart.c
@@ -1395,6 +1395,19 @@ static int lpuart32_config_rs485(struct uart_port *port, struct ktermios *termio
 
 	unsigned long modem = lpuart32_read(&sport->port, UARTMODIR)
 				& ~(UARTMODIR_TXRTSPOL | UARTMODIR_TXRTSE);
+	u32 ctrl;
+
+	/* TXRTSE and TXRTSPOL only can be changed when transmitter is disabled. */
+	ctrl = lpuart32_read(&sport->port, UARTCTRL);
+	if (ctrl & UARTCTRL_TE) {
+		/* wait for the transmit engine to complete */
+		lpuart32_wait_bit_set(&sport->port, UARTSTAT, UARTSTAT_TC);
+		lpuart32_write(&sport->port, ctrl & ~UARTCTRL_TE, UARTCTRL);
+
+		while (lpuart32_read(&sport->port, UARTCTRL) & UARTCTRL_TE)
+			cpu_relax();
+	}
+
 	lpuart32_write(&sport->port, modem, UARTMODIR);
 
 	if (rs485->flags & SER_RS485_ENABLED) {
@@ -1414,6 +1427,10 @@ static int lpuart32_config_rs485(struct uart_port *port, struct ktermios *termio
 	}
 
 	lpuart32_write(&sport->port, modem, UARTMODIR);
+
+	if (ctrl & UARTCTRL_TE)
+		lpuart32_write(&sport->port, ctrl, UARTCTRL);
+
 	return 0;
 }